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Christian R Kowol Selected Research

Thiosemicarbazones

11/2021Liposomal formulations of anticancer copper(II) thiosemicarbazone complexes.
11/2020Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux.
10/2019Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development.
1/2019Synthesis and biological evaluation of biotin-conjugated anticancer thiosemicarbazones and their iron(III) and copper(II) complexes.
10/2018The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition.
3/2018Comparison of metabolic pathways of different α-N-heterocyclic thiosemicarbazones.
1/2016Differences in protein binding and excretion of Triapine and its Fe(III) complex.
6/2012Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones.

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Christian R Kowol Research Topics

Disease

38Neoplasms (Cancer)
11/2021 - 01/2009
6Lung Neoplasms (Lung Cancer)
01/2020 - 06/2013
5Hypoxia (Hypoxemia)
03/2021 - 11/2014
3Carcinoma (Carcinomatosis)
03/2021 - 11/2007
3Hematologic Diseases (Blood Diseases)
01/2020 - 01/2016
3Colonic Neoplasms (Colon Cancer)
01/2019 - 03/2014
1Colorectal Neoplasms (Colorectal Cancer)
10/2021
1Leukemia
03/2021
1Sarcoma (Soft Tissue Sarcoma)
12/2020
1Iron Overload
10/2019
1Malaria
10/2019
1Virus Diseases (Viral Diseases)
10/2019
1Tuberculosis (Tuberculoses)
10/2019
1Osteosarcoma (Osteogenic Sarcoma)
11/2018
1Breast Neoplasms (Breast Cancer)
01/2016
1Necrosis
10/2014
1Acute Promyelocytic Leukemia
06/2013
1Mesothelioma
06/2013
1Hematologic Neoplasms (Hematological Malignancy)
06/2012

Drug/Important Bio-Agent (IBA)

123-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine)IBA
11/2021 - 01/2010
11Pharmaceutical PreparationsIBA
10/2021 - 06/2013
10ProdrugsIBA
10/2021 - 11/2014
8ThiosemicarbazonesIBA
11/2021 - 06/2012
7Biological ProductsIBA
03/2020 - 11/2015
6Tyrosine Kinase InhibitorsIBA
03/2021 - 11/2016
6LigandsIBA
03/2021 - 01/2009
4MetalsIBA
01/2019 - 11/2007
3PlatinumIBA
10/2021 - 06/2017
3Oxaliplatin (Eloxatin)FDA LinkGeneric
10/2021 - 03/2017
3AlbuminsIBA
10/2021 - 03/2017
3ponatinibIBA
03/2021 - 11/2018
3Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
12/2018 - 01/2017
2CobaltIBA
03/2021 - 12/2020
2Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
03/2021 - 11/2014
2Oxygen (Dioxygen)IBA
03/2021 - 11/2016
2maleimideIBA
01/2021 - 03/2017
2IronIBA
12/2020 - 10/2019
2CopperIBA
11/2020 - 01/2020
2PD 173074IBA
12/2018 - 11/2018
2nintedanibIBA
11/2018 - 01/2017
2Peptides (Polypeptides)IBA
06/2017 - 01/2017
2ErbB Receptors (EGF Receptor)IBA
06/2017 - 06/2013
2Cisplatin (Platino)FDA LinkGeneric
03/2017 - 12/2012
2IntegrinsIBA
01/2017 - 10/2014
2Erlotinib Hydrochloride (CP 358,774)FDA Link
11/2016 - 06/2013
2GalliumIBA
10/2014 - 11/2007
1CaveolinsIBA
10/2021
1ClathrinIBA
10/2021
1Glutathione (Reduced Glutathione)IBA
11/2020
1LipidsIBA
01/2020
1CrizotinibIBA
01/2020
1trans-sodium crocetinate (crocetin)IBA
01/2020
1satraplatin (JM 216)IBA
12/2019
1Acetates (Acetic Acid Esters)FDA Link
12/2019
1ChloridesIBA
12/2019
1Chelating AgentsIBA
10/2019
1Deferoxamine (Desferal)FDA LinkGeneric
10/2019
1Cathepsin BIBA
01/2019
1Biotin (Vitamin H)FDA Link
01/2019
1AntacidsIBA
12/2018
1Liposomes (Liposome)IBA
11/2018
1poly(lactide) (polylactic acid)IBA
11/2018
1CaspasesIBA
10/2018
1bafilomycin A1IBA
01/2017
1Chloroquine (Aralen)FDA LinkGeneric
01/2017
1Sunitinib (Sutent)FDA Link
11/2016
1LipofectamineIBA
01/2016
1VanadiumIBA
11/2015
1Activating Transcription FactorsIBA
03/2014
1Polysorbates (PSML)FDA Link
01/2014
1indazolium trans- (tetrachlorobis(1H- indazole)ruthenate (III))IBA
01/2014
1SolutionsIBA
01/2014
1Arsenic Trioxide (Trisenox)FDA Link
06/2013
1MitogensIBA
06/2013
1Proteins (Proteins, Gene)FDA Link
06/2013
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
06/2013
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
06/2013
1Lipid Bilayers (Lipid Bilayer)IBA
06/2011
1RutheniumIBA
11/2007
12-acetylpyridineIBA
11/2007

Therapy/Procedure

10Therapeutics
03/2021 - 06/2013
3Drug Therapy (Chemotherapy)
10/2021 - 01/2018
1Transplantation
11/2018
1Oral Administration
01/2017
1Traditional Medicine (Folk Remedies)
06/2013